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- Title
Effect of culture conditions on the phenotype of THP-1 monocyte cell line.
- Authors
Aldo, Paulomi B; Craveiro, Vinicius; Guller, Seth; Mor, Gil
- Abstract
Macrophage function has many implications in a variety of diseases. Understanding their biology becomes imperative when trying to elucidate immune cell interactions with their environment, and in vitro cell lines allow researchers to manipulate these interactions. A common cell line used is THP-1, a promyeloid cell line suggestive to outside factors, and therefore sensitive to culture conditions. In this study, we describe how culture conditions can alter THP-1 morphology and in turn affect their response to differentiation stimuli.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2013, Vol 70, Issue 1, p80
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/aji.12129