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- Title
Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis.
- Authors
Mulla, Melissa J; Myrtolli, Kledia; Tadesse, Serkalem; Stanwood, Nancy L; Gariepy, Aileen; Guller, Seth; Norwitz, Errol R; Abrahams, Vikki M
- Abstract
There is a strong correlation between intrauterine bacterial infection and preterm labor. While inflammation is a common mechanism, certain pathogens may trigger placental apoptosis. TLR2 activation by gram-positive bacterial peptidoglycan (PDG) induces first-trimester trophoblast apoptosis and decreased IL-6 secretion. This is dependent upon the presence of TLR1 and the absence of TLR6 and both TLR2 coreceptors. As TLR10 is also a TLR2 coreceptor, the objective of this study was to determine its expression and function in the trophoblast.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2013, Vol 69, Issue 5, p449
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/aji.12065