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- Title
Effect of FASN gene on milk yield and milk composition in the Chinese Holstein dairy population.
- Authors
Alim, M A; Wang, P; Wu, X P; Li, C; Cui, X G; Zhang, S L; Zhang, Q; Zhang, Y; Sun, D X
- Abstract
Fatty acid synthase (FASN) is a multifunctional protein that catalyzes de novo synthesis of fatty acids in cells. It plays a key role in the lipid biosynthesis as well as in the general metabolism of all living animals. We herein investigated polymorphisms of FASN. As a result, six single nucleotide polymorphisms (SNPs) were found and then genotyped in 752 Chinese Holstein cows. It was found that g.17924A>G was non-synonymous, g.13965 C>T, g.16907 T>C and g.18663T>C were synonymous mutations and two other two SNPs, g.8948 C>T (ss491228481) and g.14439T>C (rs133498277), were in intronic sequences of the gene. All such identified SNPs were found to be associated with milk yield and composition traits (P = 0.0441 to <0.0001). Significant additive and allele substitution effects were observed for three yield traits at all six loci as well (P < 0.05 to <0.01). Complete linkage disequilibrium among the five SNPs, with the exception of g.8948 C>T, was observed.
- Publication
Animal genetics, 2014, Vol 45, Issue 1, p111
- ISSN
1365-2052
- Publication type
Journal Article
- DOI
10.1111/age.12089