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- Title
Genetic resistance to liver fibrosis on A/J mouse chromosome 17.
- Authors
DeSantis, David A; Lee, Peter; Doerner, Stephanie K; Ko, Chih-Wei; Kawasoe, Jean H; Hill-Baskin, Annie E; Ernest, Sheila R; Bhargava, Prerna; Hur, Kyu Yeon; Cresci, Gail A; Pritchard, Michele T; Lee, Chih-Hao; Nagy, Laura E; Nadeau, Joseph H; Croniger, Colleen M
- Abstract
Because the histological and biochemical progression of liver disease is similar in alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH), we hypothesized that the genetic susceptibility to these liver diseases would be similar. To identify potential candidate genes that regulate the development of liver fibrosis, we studied a chromosome substitution strain (CSS-17) that contains chromosome 17 from the A/J inbred strain substituted for the corresponding chromosome on the C57BL/6J (B6) genetic background. Previously, we identified quantitative trait loci (QTLs) in CSS-17, namely obesity-resistant QTL 13 and QTL 15 (Obrq13 and Obrq15, respectively), that were associated with protection from diet-induced obesity and hepatic steatosis on a high-fat diet.
- Publication
Alcoholism, clinical and experimental research, 2013, Vol 37, Issue 10, p1668
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/acer.12157