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- Title
Shifts in discriminative control with increasing periods of recovery in the rat.
- Authors
Ginsburg, Brett C; Lamb, Richard J
- Abstract
During recovery from alcoholism, other behavior likely increases. The development of alternative behavior may reduce attention to alcohol-associated stimuli. This could result in greater persistence of the alternative behavior when individuals again encounter alcohol-associated stimuli that might precipitate relapse. Developing animal models of this process could facilitate a better understanding of the mechanisms involved in relapse and recovery. However, current preclinical models of recovery and relapse rarely measure alternative behavior. Thus, our objective was to establish a procedure in rats in which an increase in alternative behavior (responding for food) reduced responding for ethanol (EtOH). The amount of responding for food and EtOH was then assessed after re-exposure to the alcohol-associated stimulus after varying the number of preceding sessions of increased responding for food and reduced responding for EtOH. These results were compared with those from a parallel group responding for saccharin solution instead of EtOH.
- Publication
Alcoholism, clinical and experimental research, 2013, Vol 37, Issue 6, p1033
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/acer.12048