We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Common pathogenetic pathways in allergic and irritant contact dermatitis.
- Authors
Brasch, J; Burgard, J; Sterry, W
- Abstract
Despite their different pathogeneses, allergic and irritant contact dermatitis show a remarkable similarity with respect to clinical appearance, histology, and immunohistology. To further analyze this apparent contradiction, our study was designed to meticulously compare cellular infiltrates in irritant and allergic patch-test reactions by immunostaining with a broad panel of monoclonal antibodies. For this purpose, skin biopsies from allergic and irritant patch-test reactions of similar inflammatory degree were obtained from the same probands. We found that after 72 h both types of reaction were characterized by an identical dermal infiltrate consisting mainly of memory T cells, many of which were activated, and macrophages. Dermal and epidermal Langerhans cell density and HLA--DR expression of keratinocytes were also virtually identical. Our results show that antigen recognition by specific memory T cells as well as irritants can finally induce the same pattern of inflammation, including activation of T cells obviously independent of exogenous antigen.
- Publication
The Journal of investigative dermatology, 1992, Vol 98, Issue 2, p166
- ISSN
0022-202X
- Publication type
Journal Article
- DOI
10.1111/1523-1747.ep12555804