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- Title
Effect of dimethylsulfoxide concentration on the permeability of neonatal rat stratum corneum to alkanols.
- Authors
Al-Saidan, S M; Selkirk, A B; Winfield, A J
- Abstract
The effect of dimethylsulfoxide (DMSO) concentration on the permeability of neonatal rat stratum corneum to 14C labeled propan-1-ol and hexan-1-ol was studied in vitro. The permeability coefficients were determined from a range of DMSO-water systems. After soaking in water overnight, the same stratum corneum was used with water as both delivery and recipient phases for the alkanols. Concentrations below 70% DMSO reduced the penetration rate as a result of the solvent effect of DMSO and the formation of a DMSO-alkanol complex. Above 70% DMSO permeability increased, with a permeability coefficient greater than that from water being achieved at concentrations in excess of 80% DMSO. The second run, with water as delivery phase, showed that the effect was reversible below 70% DMSO, but that at higher concentrations DMSO had produced an irreversible change in the permeability of stratum corneum. We hypothesize a hydrogen bond-mediated mechanism for the increased permeability.
- Publication
The Journal of investigative dermatology, 1987, Vol 89, Issue 4, p426
- ISSN
0022-202X
- Publication type
Journal Article
- DOI
10.1111/1523-1747.ep12471784