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- Title
Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes.
- Authors
Gruber, B L; Baeza, M L; Marchese, M J; Agnello, V; Kaplan, A P
- Abstract
The prevalence of autoantibodies of immunoglobulin G (IgG) and immunoglobulin M (IgM) classes directed against myeloma immunoglobulin E (IgE) were determined in distinct subsets of urticaria, using an enzyme immunoassay. IgG anti-IgE antibodies were found in five of nine patients (55%) with cold urticaria, four of eight patients (50%) with urticarial vasculitis, and three of six patients (50%) with chronic urticaria. IgM anti-IgE antibodies were found exclusively in cold urticaria (two of nine patients, 22%). Heating of these sera increased the binding to IgE, suggesting immune complex formation. Several positive sera were capable of inducing histamine release from normal peripheral basophils and caused a wheal-flare response upon intradermal injection. Sera containing such autoantibodies from three cold urticaria patients were studied for passive transfer of cold sensitivity. One serum containing IgG anti-IgE gave a strongly positive transfer test at 5 h but not 48 h, suggesting a pathogenic role for the IgG.
- Publication
The Journal of investigative dermatology, 1988, Vol 90, Issue 2, p213
- ISSN
0022-202X
- Publication type
Journal Article
- DOI
10.1111/1523-1747.ep12462239