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- Title
The gene for Bazex-Dupré-Christol syndrome maps to chromosome Xq.
- Authors
Vabres, P; Lacombe, D; Rabinowitz, L G; Aubert, G; Anderson, C E; Taieb, A; Bonafé, J L; Hors-Cayla, M C
- Abstract
Bazex-Dupré-Christol syndrome is an inherited condition with skin cancer predisposition characterized by follicular atrophoderma, hypotrichosis, and early onset of multiple basal cell carcinomas. Previous reports suggested an X-linked mode of inheritance. We therefore performed linkage analysis with microsatellite markers of the X chromosome in three families. We obtained evidence for X-linkage and regional assignment to Xq24-q27 of this syndrome (maximal lod score = 5.26 with a recombination fraction of 0% at the DXS1192 locus). This represents a first step towards the identification of a gene involved in hair follicle development and skin tumor formation.
- Publication
The Journal of investigative dermatology, 1995, Vol 105, Issue 1, p87
- ISSN
0022-202X
- Publication type
Journal Article
- DOI
10.1111/1523-1747.ep12313359