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- Title
State of the art: the role of citrulline as biomarker in patients with chemotherapy- or graft-versus-host-disease-induced mucositis.
- Authors
Dekker, Ingeborg M; Bruggink, Hanneke; van der Meij, Barbara S; Wierdsma, Nicolette J
- Abstract
Serum or plasma citrulline levels are used as biomarker for a broad spectrum of intestinal functions. During high-dose chemotherapy, citrulline levels are decreased due to mucositis, a common side effect of chemotherapy. This may decrease intestinal function and result in diarrhea. In this review, most recent studies investigating citrulline as biomarker for intestinal function are discussed, with focus on patients with oncological diseases, specifically hematological malignancies with chemotherapy- or Graft-versus-Host-disease (GVHD)-induced mucositis.
- Publication
Current opinion in clinical nutrition and metabolic care, 2021, Vol 24, Issue 5, p416
- ISSN
1473-6519
- Publication type
Journal Article
- DOI
10.1097/MCO.0000000000000773