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- Title
Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis.
- Authors
Xie, Wen; Rimm, David L; Lin, Yong; Shih, Weichung J; Reiss, Michael
- Abstract
Based largely on in vitro investigations and animal studies, investigators believe that disruptions of transforming growth factor-beta (TGF-beta) signaling contribute to the development and progression of human colorectal cancer. The purpose of this study was to directly assess the status of the TGF-beta signaling pathway in colorectal cancer and determine the effects of its disruption on clinical behavior and outcome.
- Publication
Cancer journal (Sudbury, Mass.), 2003, Vol 9, Issue 4, p302
- ISSN
1528-9117
- Publication type
Journal Article
- DOI
10.1097/00130404-200307000-00013