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- Title
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
- Authors
Kulke, Matthew H; Demetri, George D; Sharpless, Norman E; Ryan, David P; Shivdasani, Ramesh; Clark, Jeffrey S; Spiegelman, Bruce M; Kim, Haesook; Mayer, Robert J; Fuchs, Charles S
- Abstract
Troglitazone, a potent activator of the peroxisome proliferator-activated receptor-gamma, induces tumor differentiation in human liposarcomas and causes regression of tumors that are derived from human colon cancer cells in nude mice. We therefore assessed the efficacy of troglitazone in the treatment of metastatic colon cancer in humans.
- Publication
Cancer journal (Sudbury, Mass.), 2002, Vol 8, Issue 5, p395
- ISSN
1528-9117
- Publication type
Journal Article
- DOI
10.1097/00130404-200209000-00010