We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Conjugated linoleic acid and the control of cancer and obesity.
- Authors
Pariza, M W; Park, Y; Cook, M E
- Abstract
The effects of conjugated linoleic acid (CLA) in animals are reviewed. In most of the CLA preparations that have been investigated to date for biological activity, two CLA isomers are present in about equal concentrations: cis-9,trans-11 CLA, and trans-10,cis-12 CLA. The occurrence of these isomers in foods and their production by rumen microorganisms are discussed. Potential mechanisms of action as regards the effects of CLA on cancer and body composition are reviewed, including recent evidence that body composition changes are produced by the trans-10,cis-12 CLA isomer. Evidence is presented indicating that CLA may modulate cellular response to tumor necrosis factor-alpha (TNF-alpha). The mechanistic implications of this finding are considered.
- Publication
Toxicological sciences : an official journal of the Society of Toxicology, 1999, Vol 52, Issue 2 Suppl, p107
- ISSN
1096-6080
- Publication type
Journal Article
- DOI
10.1093/toxsci/52.suppl_1.107