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- Title
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
- Authors
Potkin, Steven G; Turner, Jessica A; Guffanti, Guia; Lakatos, Anita; Fallon, James H; Nguyen, Dana D; Mathalon, Daniel; Ford, Judith; Lauriello, John; Macciardi, Fabio; FBIRN
- Abstract
Genome-wide association studies (GWASs) are increasingly used to identify risk genes for complex illnesses including schizophrenia. These studies may require thousands of subjects to obtain sufficient power. We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait (QT) in the context of a GWAS in schizophrenia.
- Publication
Schizophrenia bulletin, 2009, Vol 35, Issue 1, p96
- ISSN
0586-7614
- Publication type
Journal Article
- DOI
10.1093/schbul/sbn155