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- Title
North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research.
- Authors
Addington, Jean; Cadenhead, Kristin S; Cannon, Tyrone D; Cornblatt, Barbara; McGlashan, Thomas H; Perkins, Diana O; Seidman, Larry J; Tsuang, Ming; Walker, Elaine F; Woods, Scott W; Heinssen, Robert; North American Prodrome Longitudinal Study
- Abstract
This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and nonpsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.
- Publication
Schizophrenia bulletin, 2007, Vol 33, Issue 3, p665
- ISSN
0586-7614
- Publication type
Journal Article
- DOI
10.1093/schbul/sbl075