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- Title
Defining treatment refractoriness in schizophrenia.
- Authors
Meltzer, H Y
- Abstract
The criteria for treatment refractoriness for the use of clozapine are necessarily set at a high level because of the potential risk of agranulocytosis with this treatment. However, a more liberal definition should be considered to better appreciate the limitations of current therapies and prepare for switching to the next generation of clozapine-like drugs that do not cause agranulocytosis. It is suggested that failure of therapy to bring about the best premorbid level of functioning be considered as a starting point for treatment-resistance.
- Publication
Schizophrenia bulletin, 1990, Vol 16, Issue 4, p563
- ISSN
0586-7614
- Publication type
Journal Article
- DOI
10.1093/schbul/16.4.563