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- Title
Brain magnetic resonance imaging: approaches for investigating schizophrenia.
- Authors
Pfefferbaum, A; Lim, K O; Rosenbloom, M; Zipursky, R B
- Abstract
Magnetic resonance imaging (MRI) offers the potential for identifying, in vivo, specific brain abnormalities associated with schizophrenia. The detection of small morphological differences in areas such as the prefrontal cortex, limbic structures, and basal ganglia requires attention to a number of technical and methodological details. The effects of age, height, sex, head size, and overall tissue loss are of particular concern and are discussed. MRI acquisition and processing techniques for improving gray/white tissue contrast and image resolution are described, as are techniques for quantitative, volumetric measurement of localized regions of interest and specific brain structures as well as of the brain as a whole. Techniques for evaluating frontal lobes, temporal lobes, and basal ganglia integrity are reviewed, and recent observations on these brain regions in patients with schizophrenia are described.
- Publication
Schizophrenia bulletin, 1990, Vol 16, Issue 3, p453
- ISSN
0586-7614
- Publication type
Journal Article
- DOI
10.1093/schbul/16.3.453