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- Title
Expression of Wnt pathway mediators in metaplasic tissue in animal model and clinical samples of tendinopathy.
- Authors
Lui, Pauline Po Yee; Lee, Yuk Wa; Wong, Yin Mei; Zhang, Xiaoling; Dai, Kerong; Rolf, Christer Gustav
- Abstract
Tissue metaplasia is observed in both ossified failed healing animal model and clinical samples of tendinopathy. The Wnt signalling pathway plays a vital role in pathological calcification. We hypothesized that the Wnt signalling pathway might contribute to tissue metaplasia and failed healing in tendinopathy. This study aimed to examine the spatial-temporal expression of Wnt pathway mediators in an ossified failed tendon healing animal model and clinical samples of tendinopathy. The effect of Wnt3a on the osteogenic differentiation of tendon-derived stem cells (TDSCs) was also examined.
- Publication
Rheumatology (Oxford, England), 2013, Vol 52, Issue 9, p1609
- ISSN
1462-0332
- Publication type
Journal Article
- DOI
10.1093/rheumatology/ket214