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- Title
Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1.
- Authors
Mozaffarian, N; Wiedeman, A E; Stevens, A M
- Abstract
Antigen-presenting cells (APC) play critical roles in establishing and maintaining peripheral tolerance. This is accomplished in part via expression of negative co-stimulatory molecules such as programmed death ligand-1 (PD-L1) on tolerogenic APC, such as immature myeloid dendritic cells (mDC). Several studies have strongly linked dysfunction of APC, including mDC, to the pathogenesis of SLE. The objective of this study was to determine whether APC expressed PD-L1 protein at normal levels during active lupus.
- Publication
Rheumatology (Oxford, England), 2008, Vol 47, Issue 9, p1335
- ISSN
1462-0332
- Publication type
Journal Article
- DOI
10.1093/rheumatology/ken256