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- Title
Interaction between rheumatoid arthritis and pregnancy: correlation of molecular data with clinical disease activity measures.
- Authors
Häupl, T; Østensen, M; Grützkau, A; Burmester, G-R; Villiger, P M
- Abstract
The factors that induce remission of RA during pregnancy and the relapse occurring after delivery remain an enigma. In a previous study, we investigated gene-expression profiles of peripheral blood mononuclear cells (PBMC) in patients with RA and healthy women in late pregnancy and postpartum. Profiles of samples from both groups were similar in late pregnancy with elevated monocyte and decreased lymphocyte signatures. Postpartum, in RA PBMC the high level of monocyte transcripts persisted. Further increase was observed in adhesion, migration and signalling processes related to monocytes but also in lymphocytes despite similar clinical activity due to intensified drug treatment. This prompted us to investigate correlations between clinical parameters of disease activity and gene profiles.
- Publication
Rheumatology (Oxford, England), 2008, Vol 47 Suppl 3, piii19
- ISSN
1462-0332
- Publication type
Journal Article
- DOI
10.1093/rheumatology/ken157