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- Title
Dendritic cells pulsed with apoptotic cells activate self-reactive T-cells of lupus mice both in vitro and in vivo.
- Authors
Tzeng, T-C; Suen, J-L; Chiang, B-L
- Abstract
Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies (autoAbs) directed against the nuclear structure. Previous studies have demonstrated that dendritic cells (DCs) can process and present self-antigens (Ags) from apoptotic cells (ACs) in lupus. However, there is no direct evidence demonstrating that ACs provide self-Ags, such as histones, to stimulate autoreactive T-cells in lupus.
- Publication
Rheumatology (Oxford, England), 2006, Vol 45, Issue 10, p1230
- ISSN
1462-0324
- Publication type
Journal Article
- DOI
10.1093/rheumatology/kel106