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- Title
Tumour necrosis factor antagonists improve disease activity but not arterial stiffness in rheumatoid arthritis.
- Authors
Van Doornum, S; McColl, G; Wicks, I P
- Abstract
Systemic inflammation may play an important role in the accelerated atherosclerosis and increased cardiovascular mortality of rheumatoid arthritis (RA). Atorvastatin reduced arterial stiffness in RA patients after only 6 weeks, an effect that may be partially mediated by the immunomodulatory effects of this drug. Suppression of inflammation with tumour necrosis factor (TNF) antagonists may therefore also improve vascular function in RA; however, TNF antagonists have also been shown to cause or exacerbate congestive heart failure in patients with RA and heart failure. The aim of the present study was to examine the effect of treatment with TNF antagonists on arterial stiffness in RA patients with active disease.
- Publication
Rheumatology (Oxford, England), 2005, Vol 44, Issue 11, p1428
- ISSN
1462-0324
- Publication type
Journal Article
- DOI
10.1093/rheumatology/kei033