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- Title
The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis.
- Authors
Dayer, J M
- Abstract
The role of the cytokine network in mediating inflammation and joint destruction in rheumatoid arthritis (RA) has been investigated extensively in recent years. Interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFalpha) are two pivotal proinflammatory cytokines that have been shown to contribute to the clinical manifestations of RA. The ability of IL-1 to drive inflammation and joint erosion and to inhibit tissue repair processes has been clearly established in in vitro systems and animal models. Under physiological conditions, the activity of IL-1 is balanced by IL-1 receptor antagonist (IL-1R alpha). Understanding of the respective roles of IL-1 and IL-1R alpha in conditions of health and disease has led to the development of a recombinant IL-1ra, anakinra (Kineret; Amgen Inc., Thousand Oaks, CA), which offers a new therapeutic modality for RA.
- Publication
Rheumatology (Oxford, England), 2003, Vol 42 Suppl 2, pii3
- ISSN
1462-0324
- Publication type
Journal Article
- DOI
10.1093/rheumatology/keg326