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- Title
Influence of therapy with chimeric monoclonal tumour necrosis factor-alpha antibodies on intracellular cytokine profiles of T lymphocytes and monocytes in rheumatoid arthritis patients.
- Authors
Schuerwegh, A J; Van Offel, J F; Stevens, W J; Bridts, C H; De Clerck, L S
- Abstract
It has been shown that T lymphocytes and monocytes/macrophages, producing pro-inflammatory cytokines, play a pivotal role in the pathophysiology of rheumatoid arthritis (RA). In recent placebo-controlled double-blind randomized studies, chimeric (human/mouse) tumour necrosis factor-alpha (TNFalpha) antibodies (cA2) proved to be very effective in improving clinical disease activity and reducing inflammatory parameters in RA.
- Publication
Rheumatology (Oxford, England), 2003, Vol 42, Issue 4, p541
- ISSN
1462-0324
- Publication type
Journal Article
- DOI
10.1093/rheumatology/keg171