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- Title
Evidence from clinical trials and long-term observational studies that disease-modifying anti-rheumatic drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 review.
- Authors
Pincus, T; Ferraccioli, G; Sokka, T; Larsen, A; Rau, R; Kushner, I; Wolfe, F
- Abstract
Earlier reports, including a comprehensive 1983 review, had indicated that slowing of radiographic progression was relatively unusual in treatment of rheumatoid arthritis (RA) using traditional disease modifying anti-rheumatic drugs. However, in recent years, slowing of radiographic progression has been documented in a number of clinical trials, as well as long-term observational studies, with use of (in alphabetical order) adalimumab, anakinra, corticosteroids, cyclophosphamide, cyclosporin, etanercept, gold salts, infliximab, leflunomide, methotrexate and sulphasalazine. At this time, disease modification is a realistic goal in the clinical care of patients with RA. Documentation of improved long-term outcomes requires long-term observational data over 5-20 yr to supplement data from randomized controlled clinical trials over 6-24 months.
- Publication
Rheumatology (Oxford, England), 2002, Vol 41, Issue 12, p1346
- ISSN
1462-0324
- Publication type
Journal Article
- DOI
10.1093/rheumatology/41.12.1346