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- Title
A polymorphism within the interleukin 1 receptor antagonist (IL-1Ra) gene is associated with ankylosing spondylitis.
- Authors
McGarry, F; Neilly, J; Anderson, N; Sturrock, R; Field, M
- Abstract
Genetic factors that predispose individuals to ankylosing spondylitis (AS) are not fully understood, but are unlikely to be restricted to HLA-B27. Proinflammatory cytokines are implicated in the development of sacroiliitis. We have examined the allele frequencies of three polymorphic sites in the interleukin (IL)-1 genes in AS patients to investigate whether genetic regulation of IL-1 production could be implicated in AS pathogenesis.
- Publication
Rheumatology (Oxford, England), 2001, Vol 40, Issue 12, p1359
- ISSN
1462-0324
- Publication type
Journal Article
- DOI
10.1093/rheumatology/40.12.1359