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- Title
Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis.
- Authors
Tomita, T; Takano, H; Tomita, N; Morishita, R; Kaneko, M; Shi, K; Takahi, K; Nakase, T; Kaneda, Y; Yoshikawa, H; Ochi, T
- Abstract
Numerous cytokines are expressed in lesions of synovial hyperplasia of patients with rheumatoid arthritis (RA), and their pathophysiological contributions have been the subject of speculation. These genes are regulated by the transcription factor NFkappaB which in turn is activated by tumour necrosis factor-alpha (TNF-alpha) and cytokines. In this study we examined the inhibition of the production of pro-inflammatory cytokines, adhesion molecule and matrix metalloproteinase (MMP) from synovial tissue of patients with RA by the introduction of synthetic double-stranded DNA with high affinity for the NFkappaB binding site.
- Publication
Rheumatology (Oxford, England), 2000, Vol 39, Issue 7, p749
- ISSN
1462-0324
- Publication type
Journal Article
- DOI
10.1093/rheumatology/39.7.749