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- Title
Long-term persistence after acute Q fever of non-infective Coxiella burnetii cell components, including antigens.
- Authors
Sukocheva, O A; Marmion, B P; Storm, P A; Lockhart, M; Turra, M; Graves, S
- Abstract
Previous studies of inciting factors for a prolonged post-infection fatigue syndrome after Q fever (variously termed QFS or Q fever associated CFS/ME in the literature) showed that after the acute infection a high proportion of asymptomatic and QFS patients had Q fever antibody and also low levels in PBMC and bone marrow of Coxiella burnetii (C.b.) DNA with PCR assays directed against three different target sequences in different parts of the coxiella genome. Attempts to isolate a strain of C.b. in A/J mice, and cell culture from PCR positive PBMC and bone marrow were consistently negative. The detailed composition of the persisting coxiella residues remains to be defined.
- Publication
QJM : monthly journal of the Association of Physicians, 2010, Vol 103, Issue 11, p847
- ISSN
1460-2393
- Publication type
Journal Article
- DOI
10.1093/qjmed/hcq113