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- Title
Genomic signature: characterization and classification of species assessed by chaos game representation of sequences.
- Authors
Deschavanne, P J; Giron, A; Vilain, J; Fagot, G; Fertil, B
- Abstract
We explored DNA structures of genomes by means of a new tool derived from the "chaotic dynamical systems" theory (the so-called chaos game representation [CGR]), which allows the depiction of frequencies of oligonucleotides in the form of images. Using CGR, we observe that subsequences of a genome exhibit the main characteristics of the whole genome, attesting to the validity of the genomic signature concept. Base concentrations, stretches (runs of complementary bases or purines/pyrimidines), and patches (over- or underexpressed words of various lengths) are the main factors explaining the variability observed among sequences. The distance between images may be considered a measure of phylogenetic proximity. Eukaryotes and prokaryotes can be identified merely on the basis of their DNA structures.
- Publication
Molecular biology and evolution, 1999, Vol 16, Issue 10, p1391
- ISSN
0737-4038
- Publication type
Journal Article
- DOI
10.1093/oxfordjournals.molbev.a026048