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- Title
Two novel gene orders and the role of light-strand replication in rearrangement of the vertebrate mitochondrial genome.
- Authors
Macey, J R; Larson, A; Ananjeva, N B; Fang, Z; Papenfuss, T J
- Abstract
Two novel mitochondrial gene arrangements are identified in an agamid lizard and a ranid frog. Statistical tests incorporating phylogeny indicate a link between novel vertebrate mitochondrial gene orders and movement of the origin of light-strand replication. A mechanism involving errors in light-strand replication and tandem duplication of genes is proposed for rearrangement of vertebrate mitochondrial genes. A second mechanism involving small direct repeats also is identified. These mechanisms implicate gene order as a reliable phylogenetic character. Shifts in gene order define major lineages without evidence of parallelism or reversal. The loss of the origin of light-strand replication from its typical vertebrate position evolves in parallel and, therefore, is a less reliable phylogenetic character. Gene junctions also evolve in parallel. Sequencing across multigenic regions, in particular transfer RNA genes, should be a major focus of future systematic studies to locate novel gene orders and to provide a better understanding of the evolution of the vertebrate mitochondrial genome.
- Publication
Molecular biology and evolution, 1997, Vol 14, Issue 1, p91
- ISSN
0737-4038
- Publication type
Journal Article
- DOI
10.1093/oxfordjournals.molbev.a025706