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- Title
Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator.
- Authors
Miura, N; Ishida, N; Hoshino, M; Yamauchi, M; Hara, T; Ayusawa, D; Kawakita, M
- Abstract
We have cloned a cDNA that codes for a putative human UDP-galactose translocator (UGT) protein. The cDNA contained an open reading frame of 1,179 base pairs encoding a novel protein of 393 amino acids. Introduction of the open reading frame sequence into a UGT-deficient mouse cell line, Had-1, complemented the genetic defect of the mutant, namely the inability to transport UDP-galactose from the cytosol to the Golgi lumen, as judged from the lectin-sensitivity spectrum of the transformant. To our knowledge, this is the first mammalian nucleotide-sugar translocator whose cDNA sequence has been described.
- Publication
Journal of biochemistry, 1996, Vol 120, Issue 2, p236
- ISSN
0021-924X
- Publication type
Journal Article
- DOI
10.1093/oxfordjournals.jbchem.a021404