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- Title
Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor.
- Authors
Tomida, M; Gotoh, O
- Abstract
The human gene encoding the differentiation-stimulating factor (D-factor)/leukemia inhibitory factor (LIF) receptor was cloned and its structure was analyzed. The gene spans more than 70 kilobases and contains 20 exons. The D-factor/LIF receptor can be subdivided into several regions; cytokine receptor homologous domain 1, an Ig-like domain, cytokine receptor homologous domain 2, three fibronectin type III domains, a transmembrane domain and a cytoplasmic region. Each domain of the receptor is encoded by a set of exons. There is a TATA sequence upstream of the transcription initiation site. One unit of the Alu sequence is present in the 5' flanking region. An NF-IL6 site is located 31 bases downstream of the transcription initiation site.
- Publication
Journal of biochemistry, 1996, Vol 120, Issue 1, p201
- ISSN
0021-924X
- Publication type
Journal Article
- DOI
10.1093/oxfordjournals.jbchem.a021386