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- Title
Sample size requirements in case-only designs to detect gene-environment interaction.
- Authors
Yang, Q; Khoury, M J; Flanders, W D
- Abstract
With advances in molecular genetic technology, more studies will examine gene-environment interaction in disease etiology. If the primary purpose of the study is to estimate the effect of gene-environment interaction in disease etiology, one can do so without employing controls. The case-only design has been promoted as an efficient and valid method for screening for gene-environment interaction. The authors derive a method for estimating sample size requirements, present sample size estimates, and compare minimum sample size requirements to detect gene-environment interaction in case-only studies with case-control studies. Assuming independence between exposure and genotype in the population, the authors believe that the case-only design is more efficient than a case-control design in detecting gene-environment interaction. They also illustrate a method to estimate sample size when information on marginal effects (relative risk) of exposure and genotype is available from previous studies.
- Publication
American journal of epidemiology, 1997, Vol 146, Issue 9, p713
- ISSN
0002-9262
- Publication type
Journal Article
- DOI
10.1093/oxfordjournals.aje.a009346