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- Title
High dose transdermal nicotine for fast metabolizers of nicotine: a proof of concept placebo-controlled trial.
- Authors
Schnoll, Robert A; Wileyto, E Paul; Leone, Frank T; Tyndale, Rachel F; Benowitz, Neal L
- Abstract
Smokers with a faster rate of nicotine metabolism, estimated using the ratio of 3'-hydroxycotinine (3-HC) to cotinine, have lower plasma nicotine levels and are more likely to relapse with 21 mg nicotine patch therapy, than smokers with slower rates of nicotine metabolism. Thus, faster metabolizers of nicotine may require a higher nicotine patch dose to achieve cessation.
- Publication
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Vol 15, Issue 2, p348
- ISSN
1469-994X
- Publication type
Journal Article
- DOI
10.1093/ntr/nts129