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- Title
Association between nicotinic acetylcholine receptor single nucleotide polymorphisms and smoking cessation.
- Authors
Spruell, Timothy; Colavita, Guillaume; Donegan, Tomas; Egawhary, Marco; Hurley, Michael; Aveyard, Paul; Johnstone, Elaine C; Murphy, Michael F G; Munafò, Marcus R
- Abstract
The α4β2 nicotinic receptor is of central importance in tobacco dependence, while the homomeric α7 receptor may also play a role. In this candidate gene study, we examine the association between 8 single nucleotide polymorphisms (SNPs) in genes coding for nicotinic acetylcholine receptor subunits α4 (rs1044396, rs2273504, rs2236196, and rs2273502), α7 (rs2133965 and rs4779969), and β2 (rs2072660 and rs2072661) and smoking abstinence in a cohort of quitters enrolled in a clinical trial of behavioral support.
- Publication
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012, Vol 14, Issue 8, p993
- ISSN
1469-994X
- Publication type
Journal Article
- DOI
10.1093/ntr/ntr246