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- Title
Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.
- Authors
Falcone, Mary; Jepson, Christopher; Benowitz, Neal; Bergen, Andrew W; Pinto, Angela; Wileyto, E Paul; Baldwin, Don; Tyndale, Rachel F; Lerman, Caryn; Ray, Riju
- Abstract
Genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with heaviness of smoking. The nicotine metabolite ratio (NMR), a measure of the rate of nicotine metabolism, is associated with the number of cigarettes per day (CPD) and likelihood of cessation. We tested the potential interacting effects of these two risk factors on CPD.
- Publication
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011, Vol 13, Issue 6, p498
- ISSN
1469-994X
- Publication type
Journal Article
- DOI
10.1093/ntr/ntr012