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- Title
Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers.
- Authors
Cosgrove, Kelly P; Esterlis, Irina; McKee, Sherry; Bois, Frederic; Alagille, David; Tamagnan, Gilles D; Seibyl, John P; Krishnan-Sarin, Suchitra; Staley, Julie K
- Abstract
Nicotine and tobacco smoking administration have demonstrated antinociceptive effects that are mediated by the nicotinic acetylcholine receptor containing the beta2* subunit (beta(2)*-nAChR). In this study, we examined the relationship between beta(2)*-nAChR availability and nociception during acute withdrawal in human tobacco smokers using [(123)I]5-IA-85380 ([(123)I]5-IA) and single photon emission computed tomography (SPECT) brain imaging.
- Publication
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2010, Vol 12, Issue 5, p535
- ISSN
1469-994X
- Publication type
Journal Article
- DOI
10.1093/ntr/ntq040