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- Title
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging.
- Authors
Park, Jae Mo; Recht, Lawrence D; Josan, Sonal; Merchant, Milton; Jang, Taichang; Yen, Yi-Fen; Hurd, Ralph E; Spielman, Daniel M; Mayer, Dirk
- Abstract
The metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using hyperpolarized [1-(13)C]pyruvate. Although the pyruvate dehydrogenase (PDH)-mediated flux from pyruvate to acetyl coenzyme A can be indirectly measured through the detection of carbon-13 ((13)C)-labeled bicarbonate, it has proven difficult to visualize (13)C-bicarbonate at high enough levels from injected [1-(13)C]pyruvate for quantitative analysis in brain. The aim of this study is to improve the detection of (13)C-labeled metabolites, in particular bicarbonate, in glioma and normal brain in vivo and to measure the metabolic response to dichloroacetate, which upregulates PDH activity.
- Publication
Neuro-oncology, 2013, Vol 15, Issue 4, p433
- ISSN
1523-5866
- Publication type
Journal Article
- DOI
10.1093/neuonc/nos319