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- Title
Gene-gene interactions in APOL1-associated nephropathy.
- Authors
Divers, Jasmin; Palmer, Nicholette D; Lu, Lingyi; Langefeld, Carl D; Rocco, Michael V; Hicks, Pamela J; Murea, Mariana; Ma, Lijun; Bowden, Donald W; Freedman, Barry I
- Abstract
Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non-diabetic ESKD were tested for interaction with APOL1 to identify genes modifying risk for non-diabetic nephropathy.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014, Vol 29, Issue 3, p587
- ISSN
1460-2385
- Publication type
Journal Article
- DOI
10.1093/ndt/gft423