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- Title
Somatostatin analog therapy for severe polycystic liver disease: results after 2 years.
- Authors
Hogan, Marie C; Masyuk, Tetyana V; Page, Linda; Holmes, David R, 3rd; Li, Xujian; Bergstralh, Eric J; Irazabal, Maria V; Kim, Bohyun; King, Bernard F; Glockner, James F; Larusso, Nicholas F; Torres, Vicente E
- Abstract
We showed in a randomized double-blinded placebo-controlled clinical trial that octreotide long-acting repeatable depot.® (OctLAR(®)) for 12 months reduces kidney and liver growth in autosomal dominant polycystic kidney patients with severe polycystic liver disease (PLD) and liver growth in patients with severe isolated PLD. We have now completed an open-label extension for one additional year to assess safety and clinical benefits of continued use of OctLAR for 2 years (O → O) and examined drug effect in the placebo group who crossed over to OctLAR in Year 2 (P → O).
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Vol 27, Issue 9, p3532
- ISSN
1460-2385
- Publication type
Journal Article
- DOI
10.1093/ndt/gfs152