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- Title
Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model.
- Authors
Martinez-Palli, Graciela; Hirose, Ryutaro; Liu, Tao; Xu, Fengyun; Dang, Kim; Feiner, John; Serkova, Natalie J; Niemann, Claus U
- Abstract
Immunosuppressive agents have been investigated in renal ischaemia-reperfusion injury (IRI) and have frequently demonstrated a beneficial effect. Most studies focused on treatment of the recipient at the time of transplantation. Pre-treatment of these organs before injury (pharmacological pre-conditioning) may particularly protect these organs. This study aimed to investigate the possible protective effects of donor pre-treatment with cyclosporine (CsA) or the mTOR inhibitor everolimus or their combination against IRI during renal transplantation in a rat model.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Vol 26, Issue 6, p1813
- ISSN
1460-2385
- Publication type
Journal Article
- DOI
10.1093/ndt/gfq646