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- Title
Bortezomib: a new player in pre- and post-transplant desensitization?
- Authors
Lemy, Anne; Toungouz, Michel; Abramowicz, Daniel
- Abstract
Several desensitization strategies have been investigated for the reversal of acute antibody-mediated rejection or for the removal of preformed anti-HLA antibodies, with the aim to promote access to renal transplantation. Today, their success appears limited or incomplete. Bortezomib, a selective inhibitor of the 26S proteasome, which is largely used in the treatment of multiple myeloma, could be a novel promising desensitizing agent. Its mechanism of action and preliminary clinical use in renal transplantation is reviewed here.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Vol 25, Issue 11, p3480
- ISSN
1460-2385
- Publication type
Review
- DOI
10.1093/ndt/gfq502