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- Title
Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.
- Authors
Leuenroth, Stephanie J; Bencivenga, Natasha; Chahboune, Halima; Hyder, Fahmeed; Crews, Craig M
- Abstract
Autosomal dominant polycystic kidney disease (ADPKD), a major cause of end-stage renal failure, results from genetic mutation of either polycystin-1 (Pkd1) or polycystin-2 (Pkd2). In order to develop novel therapies to treat the advancement of disease progression, numerous rodent models of different genetic backgrounds are available to study cyst development.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Vol 25, Issue 7, p2187
- ISSN
1460-2385
- Publication type
Journal Article
- DOI
10.1093/ndt/gfp777