We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy.
- Authors
Martin, Rosalind J L; McKnight, Amy J; Patterson, Christopher C; Sadlier, Denise M; Maxwell, Alexander P; Warren 3/UK GoKinD Study Group
- Abstract
Vitamin D and its analogues are reported to have renoprotective effects in chronic kidney disease including diabetic nephropathy (DN). Vitamin D(3) is converted to 1,25(OH)D(3) by CYP2R1 and CYP27B1. The biological action of 1,25(OH)D(3) is mediated via its receptor. VDR, CYP27B1 or CYP2R1 gene variants could modify the biological activity of vitamin D(3). We have conducted the first case-control association study to determine the relationship between polymorphisms in VDR, CYP27B1 and CYP2R1 genes, and the risk of DN in individuals with type 1 diabetes.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Vol 25, Issue 2, p497
- ISSN
1460-2385
- Publication type
Journal Article
- DOI
10.1093/ndt/gfp515