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- Title
Differential proteomic analysis of cyclosporine A-induced toxicity in renal proximal tubule cells.
- Authors
Puigmulé, Marta; López-Hellin, Joan; Suñé, Guillermo; Tornavaca, Olga; Camaño, Sonia; Tejedor, Alberto; Meseguer, Anna
- Abstract
The use of cyclosporine A (CsA) as a potent immunosuppressant has been limited by its severe nephrotoxic effects. The mechanisms involved are haemodynamic but also related to direct toxic effects of CsA on proximal tubule epithelial cells. We focused on defining a proteomic profile in CsA-treated proximal tubule cells to distinguish the direct impact of CsA on these cells from overlapping haemodynamically mediated phenomena that occur in an in vivo system.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Vol 24, Issue 9, p2672
- ISSN
1460-2385
- Publication type
Journal Article
- DOI
10.1093/ndt/gfp149