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- Title
Inhibitory effects of matrix metalloproteinase inhibitor ONO-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats.
- Authors
Ro, Yuuki; Hamada, Chieko; Inaba, Masanori; Io, Hiroaki; Kaneko, Kayo; Tomino, Yasuhiko
- Abstract
The activity of gelatinase, matrix metalloproteinase-2, in effluent was increased in peritoneal dialysis patients with encapsulated peritoneal sclerosis (EPS) and in chlorhexidine gluconate-induced peritoneal sclerosing (PS) animal models. The objective of the present study was to investigate the effect of matrix metalloproteinase inhibitor (ONO-4817), an anticancer agent with anti-angiogenesis and anti-infiltration effects, on the development of peritoneal fibrosis in chlorhexidine gluconate-induced PS rats.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Vol 22, Issue 10, p2838
- ISSN
0931-0509
- Publication type
Journal Article
- DOI
10.1093/ndt/gfm323