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- Title
Influence of aldosterone vs. endothelin receptor antagonism on renovascular function in liquorice-induced hypertension.
- Authors
Quaschning, T; Ruschitzka, F; Niggli, B; Lunt, C M; Shaw, S; Christ, M; Wehling, M; Lüscher, T F
- Abstract
The enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) provides mineralocorticoid receptor specificity for aldosterone by metabolizing glucocorticoids to their receptor inactive 11-dehydro derivatives. Inhibition of 11beta-HSD2 by liquorice-derived glycyrrhizic acid (GA) therefore results in sodium retention and hypertension. The present study investigated the effect of the aldosterone receptor antagonist spironolactone in comparison with the endothelin ET(A) receptor antagonist darusentan on renovascular endothelial function in liquorice-induced hypertension.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Vol 16, Issue 11, p2146
- ISSN
0931-0509
- Publication type
Journal Article
- DOI
10.1093/ndt/16.11.2146