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- Title
A deficit of calcitriol synthesis may not be the initial factor in the pathogenesis of secondary hyperparathyroidism.
- Authors
Martinez, I; Saracho, R; Montenegro, J; Llach, F
- Abstract
Secondary hyperparathyroidism (HPT) develops early in chronic renal failure (CRF) at a time when plasma calcitriol levels are normal. At this time, PTH are higher than normal controls and serum phosphorous levels are lower. A decrement in total serum Ca is noted, after an oral phosphate load, only in patients with ERF. These data suggest that factors, other than a decrease in calcitriol synthesis, may be involved in the pathogenesis of HPT. A hypothesis is forwarded suggesting that an alteration in the newly cloned calcium sensor receptor may be the earliest abnormality in the HPT, preceding a decrease in plasma calcitriol levels.
- Publication
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Vol 11 Suppl 3, p22
- ISSN
0931-0509
- Publication type
Journal Article
- DOI
10.1093/ndt/11.supp3.22