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- Title
How does DNA break during chromosomal translocations?
- Authors
Nambiar, Mridula; Raghavan, Sathees C
- Abstract
Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades, the mechanism by which chromosomes break during a translocation remains largely unknown. In this review, we summarize recent advances made in understanding the molecular mechanism of chromosomal translocations.
- Publication
Nucleic acids research, 2011, Vol 39, Issue 14, p5813
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkr223