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- Title
PROMISCUOUS: a database for network-based drug-repositioning.
- Authors
von Eichborn, Joachim; Murgueitio, Manuela S; Dunkel, Mathias; Koerner, Soeren; Bourne, Philip E; Preissner, Robert
- Abstract
The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multi-specificity of approved drugs led to block-busters in new indication areas. Therefore, the interest in systematically elucidating new areas of application for known drugs is rising. Furthermore, the knowledge, understanding and prediction of so-called off-target effects allow a rational approach to the understanding of side-effects. With PROMISCUOUS we provide an exhaustive set of drugs (25,000), including withdrawn or experimental drugs, annotated with drug-protein and protein-protein relationships (21,500/104,000) compiled from public resources via text and data mining including manual curation. Measures of structural similarity for drugs as well as known side-effects can be easily connected to protein-protein interactions to establish and analyse networks responsible for multi-pharmacology. This network-based approach can provide a starting point for drug-repositioning. PROMISCUOUS is publicly available at http://bioinformatics.charite.de/promiscuous.
- Publication
Nucleic acids research, 2011, Vol 39, Issue Database issue, pD1060
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkq1037